首页|期刊导航|中华医学杂志（英文版）|Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients
中华医学杂志（英文版）2012，Vol.125Issue(22)：4014-4017,4.DOI:10.3760/cma.j.issn.0366-6999.2012.22.019
Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients
Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients
摘要
Abstract
Background Mixed cryoglobulinemia(MC)is one of the most common and severe symptoms in chronic hepatitis C patients.The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin.Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin.Serum cryoglobulin was detected by cryoprecipitation prior to treatment.Serum hepatitis C virus(HCV)RNA levels were checked before treatment,during the fourth and 12th week of treatment,and during the 24th week after cessation of treatment.The genotype of HCV was determined at baseline.Logistic regression analysis was used to assess the factors associated with sustained virological response.Results Twenty-five patients were with MC(43.9％).Twenty-four weeks after cessation of antiviral treatment,sustained virological response achievement in MC+patients was significantly lower than that in MC-patients(32.0％ vs.75.0％,P=0.001).Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC(odds ratio:6.375;95％ Cl:1.998-20.343,P=0.002)was negatively associated with sustained virological response achievement.Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.关键词
hepatitis C/cryoglobulinemia/virological responseKey words
hepatitis C/cryoglobulinemia/virological response引用本文复制引用
FAN Xiao-hong,WU Chi-hong,WANG Li-fen,ZHENG Ying-ying,YAO Ying,LU Hai-ying,XU Xiao-yuan,WEI Lai..Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients[J].中华医学杂志（英文版）,2012,125(22):4014-4017,4.基金项目
This study was supported by the grants from the National Major Project for Infectious Diseases Control(No.2008ZX10002-013),the National Natural Science Foundation of China(No.30771906),and the Ph.D.Programs Foundation of Ministry of Education of China(No.20090001110081). （No.2008ZX10002-013）
