中医药学报2012，Vol.40Issue(6)：50-53,4.
大豆异黄酮对高脂大鼠血脂的影响
Effect of Soybean Isoflavones on Serum Lipid Level in Hyperlipidemia Rats
摘要
Abstract
Objective: To investigate the effect of different dosages of soybean isoflavones on serum lipid level in Hyperlip-idemia rats. Methods: 75 male Wistar rats were selected. In the 75 rats, 15 were given basal diet as a control group and the remaining rats were given high fat diet. After four weeks of feeding, the animals were divided into four groups randomly based on total cholesterol ( TC) value :high fat diet control group, low dose SI group (high fat diet +30mg/(kg ·d) ) , middle dose SI group (high fat diet + 90mg/(kg·d) ) , high dose SI group (high fat diet + 270mg/( kg·d) ). Continuous feeding for 12 weeks, the rats serum TC,TG, LDL levels were measured respectively at the 0,4th,8th,12th and 16th week. Results: Compared with the control group , the serum TC ,TG and LDL levels were increased in high fat diet group(P <0.05); the serum TC,LDL levels were decreased significantly in middle and high-dose SI group(P< 0.05) , the low dose SI group had no significant effect on serum TC, LDL(P >0. 05) ; the serum TG level was decreased significantly in high —dose SI group(P <0.05) , the low and middle —dose SI group had no significant effect on serum TG (P > 0. 05 ). And the more soybean isoflavones were taken by the Hyperlipidemia rats, and the more lipid -lowering effect appeared. Conclusion; Soy isoflavones can reduce the levels of TC, TG, LDL in Hyperlipidemia rats, and its effects are dose - dependent.关键词
大豆异黄酮/胆固醇/甘油三酯/低密度脂蛋白Key words
Soy isoflavones/ Cholesterol/ Triglyceride/ Low density lipoprotein分类
医药卫生引用本文复制引用
孙瑞红,李琨,滕文丽,徐冉,王慧慧,刘晓林,王宏倩..大豆异黄酮对高脂大鼠血脂的影响[J].中医药学报,2012,40(6):50-53,4.基金项目
黑龙江省教育厅科学技术研究项目(No.11531159) （No.11531159）
