癌变·畸变·突变2012，Vol.24Issue(6)：444-447,4.DOI:10.3969/j.issn.1004-616x.2012.06.010
维甲酸X受体抑制剂HX531对热带爪蟾胚胎的致畸效应
Teratogenic effects of retinoid X receptor antagonist HX531 on Xenopus tropicalis embryos
摘要
Abstract
OBJECTIVE: To investigate the teratogenic effects of HX531 on Xenopus tropicalis embryos. METHODS: Xenopus tropicalis embryos were exposed to 1-500 μg/L HX531 for 48 h. The percentages of survival, body length and malformations were measured. RESULTS: HX531 decreased the survival of embryos by 83% at the concentration of 400 μ g/L and by 97% at the concentration of 500 μ g/L. The half lethal concentration (LC50) of HX531 at 48 h was 352 |x g/L. The body length of embryos decreased by 18.4%-41.1% in 200-500 μ g/L HX531-treated groups. After 48 h of exposure, the total percentages of malformations significantly increased and reached 100% in 200-500 μ/L HX531-treated groups. HX531 also led to multiple abnormal phenotypes, including abnormal brains and eyes, narrow fins, pericardial edema and bent tails. The half-maximal effective concentration (EC50) at 48 h was 79 (μ g/L and the teratogenic index was 4.4. CONCLUSION: HX531 was a strong teratogen and that RXR played an important role in the development of vertebrate embryos.ardia关键词
维甲酸X受体/热带爪蟾/胚胎/致畸Key words
RXR antagonist/Xenous tropicalis/embryos/teratognesis分类
生物科学引用本文复制引用
朱攀,孙智,杨波,薛银刚,施华宏..维甲酸X受体抑制剂HX531对热带爪蟾胚胎的致畸效应[J].癌变·畸变·突变,2012,24(6):444-447,4.基金项目
国家自然科学基金项目(20877023) （20877023）
江苏省环境监测科研基金(1106) （1106）
