安徽医科大学学报2013，Vol.48Issue(1)：5-7,3.
杯状细胞及5-HT、SP-IR细胞在药物依赖性便秘大鼠盲肠中的表达及意义
The expression and significance of goblet cells and 5-HT and SP immunoreactive cells of appendix ofdrug-dependent constipation in rats
摘要
Abstract
Objective To study possible functions of the drug-dependent constipation by observing morphological distributions and quantitative changes of goblet cells and 5-HT and SP immunoreactive cells of appendix of the drug-dependent constipation in rats. Methods 45 SD rats were randomly divided into the normal control group, rhubarb model group and phenolphthalein model group 15 SD rats in each group. To develop model of drug-dependent constipation in rats by infusing stomach with rhubarb and phenolphthalein in two model group rats and to use the immu-nohistochemistry SABC, common histological method and cell counting for observing the morphological distributions and quantitative changes of goblet cells, 5-HT and SP immunoreactive cell of appendix in rats. Results Compared with the normal control group, the number goblet cells and 5-HT of intestine of rats decreased obviously( P < 0. 05 ) and the immunohistochemical reaction duoenum deceased in latter. Conclusion It is suggested that the changes of morphological distribution and quantity of appendix goblet cells, immune cells 5-HT may be an important factor of drug dependence constipation.关键词
大鼠/药物依赖性便秘/杯状细胞/5-羟色胺/P物质Key words
rat/drug-dependent constipation/ goblet cells/ 5-HT/SP分类
生物科学引用本文复制引用
巫全胜,高健群,钱宁,吴曙光..杯状细胞及5-HT、SP-IR细胞在药物依赖性便秘大鼠盲肠中的表达及意义[J].安徽医科大学学报,2013,48(1):5-7,3.基金项目
江西省教育厅科技项目(编号:2010GJJ10670) （编号:2010GJJ10670）
