安徽医科大学学报2013，Vol.48Issue(1)：43-46,4.
白血病异基因造血干细胞移植术后中枢神经系统复发的临床研究
Clinical study of central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation
摘要
Abstract
Objective To study central nervous system ( CNS ) relapse of leukemia after allogeneic hematopoietic stem cell transplantation ( HSCT ) in order to get the correlation factors and outcome. Methods We reviewed the data of 288 patients with leukemia ( 98ALL/85AML/6 mix-AL/99CML ) who received allogeneic HSCT in our hospital and retrospectively analyzed the incidence, risk factors, treatment and outcome of patients with CNS relapse. Results Eight patients developed CNS relapse at 160. 5 ( 95 ~ 622 ) days after HSCT with a cumulative incidence of 2. 78% . The cumulative incidences of CNS relapse in patients with and without a history of CNS involvement before HSCT were 13. 04% and 1. 89% , respectively. ALL were at higher risk for CNS relapse in patients without a history of CNS involvement before HSCT ( ALL 2. 50% , AML 2. 47% , and CML-CP 0% ). In addition, it could not show a beneficial effect of prophylactic intrathecal chemotherapy on the incidence of CNS relapse in patients without a history of CNS involvement before HSCT. Three of the eight patients were alive, and, the 2-year overall survival ( OS ) after CNS relapse was 50% . Conclusion CNS relapse is not uncommon after HSCT in patients with acute leukemia, especially with a history of CNS involvement before HSCT, and they have high mortality and poor prognosis. Early diagnosis and appropriate management are crucial to the improvement of clinical outcomes in these patients.关键词
中枢神经系统复发/白血病/异基因造血干细胞移植Key words
central nervous system relapse/ leukemia/ allogeneic HSCT分类
医药卫生引用本文复制引用
李来玲,汤宝林,朱小玉,薛磊,姚雯,朱薇波,王祖贻,王兴兵,孙自敏,刘会兰,耿良权,丁凯阳,刘欣,杨会志,韩永胜..白血病异基因造血干细胞移植术后中枢神经系统复发的临床研究[J].安徽医科大学学报,2013,48(1):43-46,4.基金项目
国家自然科学基金(编号:31101006) （编号:31101006）
安徽省115产业创新团队项目(皖人才办[2009]2号) （皖人才办[2009]2号）
安徽省高校省级科学研究项目(编号:KJ2012Z188) （编号:KJ2012Z188）
