安徽医科大学学报2013，Vol.48Issue(2)：182-184,3.
血清脂联素、瘦素与心力衰竭程度关系的研究
Study of association between serum adiponectin,serum leptin levels and congestive heart failure degree
摘要
Abstract
Objective To observe the changes of serum adiponectin, serum leptin, and study the association between serum adiponectin, serum leptin and congestive heart failure patients. Methods According to Framinghan criteria and some certain include and exclude criteria,60 patients were selected. They were assigned to groups according to NYHA Class and left ventricular ejection fraction ( LVEF ) and 45 controls were determined and contrasted. Plasm serum adiponectin, serum leptin, interleukin-6( IL-6 ) and brain natriuretic peptide( BNP ) level was estimated with ELISA. Results The serum adiponectin, serum leptin, IL-6 and BNP in congestive heart failure patients were significantly higher than that of the controls. The serum adiponectin, serum leptin, IL-6 levels were positively correlated with BNP levels and were negatively correlated with LVEF levels. The serum adiponectin, serum leptin increased with the increase of degree of congestive heart failure. Conclusion Serum adiponectin and serum leptin level are closely related to heart failure, and may be involved in occurrence and development of heart failure. The assay of the serum adiponectin, serum leptin level are one reference index in judgement of the degree of congestive heart failure.关键词
心力衰竭/脂联素/瘦素/脑型利钠肽Key words
heart failure/ adiponectin/ leptin/ brain natriuretic peptide分类
医药卫生引用本文复制引用
武琦,徐彤彤,覃泱,吕祥威..血清脂联素、瘦素与心力衰竭程度关系的研究[J].安徽医科大学学报,2013,48(2):182-184,3.基金项目
2011广西省科技厅广西科学研究与技术开发计划项目课题(编号:桂科攻1140003B-76) （编号:桂科攻1140003B-76）
2010广西医疗卫生重点科研课题(编号:重2010050) （编号:重2010050）
2012广西卫生厅课题(编号:Z2012417) （编号:Z2012417）
