安徽医科大学学报2013，Vol.48Issue(3)：207-210,4.
P2受体介导对大鼠三叉神经节神经元电压门控性钙离子通道的作用
P2X receptors mediate voltage-gated calcium channels in rat trigeminal ganglion neurons
摘要
Abstract
Objective To investigate the effect of P2 receptor on voltage-gated calcium channels in trigeminal ganglion ( TG ) neurons. Methods Acutely isolated TG neurons were used. Voltage-gated calcium channel ( VGCC ) currents were recorded by patch clamp technique. Adenosine triphosphate ( ATP ), P2X and P2Y receptor agonists were perfused respectively to observe the role of VGCC currents. Results ATP could reversibly inhibit the VGCC currents of rat TG neurons ( P < 0. 05 ). αβ-methylene ATP ( αβ-meATP ) and a P2X receptor agonist could significantly inhibit the VGCC currents of rat TG neurons ( P < 0. 05 ). However, 2-MethylthioADP ( 2-MeSADP ), a P2Y receptor agonist, had no effect on VGCC currents of rat TG neurons. Conclusion P2X receptors mediate inhibitory effect on the VGCC currents in rat.关键词
三叉神经节/P2受体/全细胞膜片钳/电压门控性钙离子通道Key words
trigeminal ganglion/ P2 receptor/ whole cell patch clamp/ voltage-gated calcium channel分类
医药卫生引用本文复制引用
孙晖,李国超,解敏,刘悦雁,李忠稳,王烈成,王元银,周健,张志愿..P2受体介导对大鼠三叉神经节神经元电压门控性钙离子通道的作用[J].安徽医科大学学报,2013,48(3):207-210,4.基金项目
国家自然科学基金(编号:81271162) （编号:81271162）
安徽省自然科学基金(编号:11040606M204) （编号:11040606M204）
上海市博士后科研基金(编号:10R21415000) （编号:10R21415000）
