安徽中医学院学报2013，Vol.32Issue(1)：50-52,3.DOI:10.3969/j.issn.1000-2219.2013.01.019
桃红四物汤对产后血瘀证大鼠血清溶血磷脂酸的影响
Effect of Taohong Siwu Decoction on Serum Level of Lysophosphatidic Acid in Rats with Postpartum Blood Stasis Syndrome
摘要
Abstract
Objective To investigate the effect of Taohong Siwu Decoction (TSD) on the serum level of lysophosphatidic acid (LPA) in rats -with postpartum blood stasis syndrome (BSS). Methods The rats in early pregnancy were administered mifepristone (8. 3 mg/kg) and misoprostol (0. 1 mg/kg) by gavage to induce a rat model of BSS. These rats were randomly divided into model group, Herba Leonuri (4. 3 g/kg) group, high-dose TSD (18. 0 g/kg) group, middle-dose TSD (9. 0 g/kg) group, low-dose TSD (4. 5 g/kg) group, and normal control group. The hemorheological indices were measured to determine the therapeutic efficacy of TSD in the treatment of BSS. The serum level of LPA was measured by enzyme-linked immunosorbent assay. Results Compared with the normal control group, the model group showed significantly increased blood viscosity, plasma viscosity, and serum level of LPA (P<0. 05 or P<0. 01). Compared with the model group, the middle-dose TSD group and Herba Leonuri group showed significantly decreased blood viscosity at low shear rate and blood viscosity at high shear rate (P<0. 05); all medication groups showed significantly decreased plasma viscosity (P<0. 05 or P<0. 01) ; the middle-dose TSD group and Herba Leonuri group showed significantly decreased serum level of LPA (P<0. 05). Conclusion TSD has marked stasis-removing effect, which may be related to its ability to decrease serum level of LPA.关键词
桃红四物汤/溶血磷脂酸/血瘀证Key words
Taohong Siwu Decoction/ lysophosphatidic acid/ blood stasis syndrome分类
医药卫生引用本文复制引用
李白坤,梁杰,朱继民,刘竹青,李珊珊,彭代银..桃红四物汤对产后血瘀证大鼠血清溶血磷脂酸的影响[J].安徽中医学院学报,2013,32(1):50-52,3.基金项目
国家自然科学基金项目(81073091) （81073091）
安徽中医学院自然科学研究基金项目(2011zr006B) （2011zr006B）
