重庆医学2013，Vol.42Issue(1)：31-32,36,3.DOI:10.3969/j.issn.1671-8348.2013.01.010
生存素和PEDF蛋白在食管癌中的表达及临床意义
Expressions of Survivin and PEDF protein in esophageal neoplasms tissue and its clinical significance
李牧 1李安桂 1王玮1
作者信息
- 1. 桂林医学院附属医院心胸外科,广西桂林,541001
- 折叠
摘要
Abstract
Objective To explore expression of Survivin and pigment epithelium-derived factor(PEDF)in esophageal carcinoma tissue and its clinical significance .Methods Streptavidin-perosidase immunohistochemistry method was employed to detect Survivin and PEDF protein expression in 86 cases of esophageal carcinoma tissue ,6 cases of normal and inflammation tissue .Results The positive rates of Survivin and PEDF protein expression in esophageal carcinoma tissue were significant higher than those in normal tissue(P<0.05) .Survivin and PEDF protein expression in esophageal carcinoma tissue were related to TNM staging ,tumor differentiation and lymph node metastasis ,and showed no correlation with age and gender of patients .There was a negative correlation between Survivin and PEDF protein expression in 86 cases of esophageal carcinoma tissue (r= -0 .353 ,Ρ=0 .003) .Conclusion Survivin and PEDF protein have antagonistic role in tumor formation ,and their co-detection can be of great importance for estimation of malignant degree and prognosis of esophageal carcinoma .关键词
食管肿瘤/免疫组织化学/生存素/色素上皮衍生因子Key words
esophageal neoplasms/immunohistochemistry /surviving /pigment epithelium-derived factor引用本文复制引用
李牧,李安桂,王玮..生存素和PEDF蛋白在食管癌中的表达及临床意义[J].重庆医学,2013,42(1):31-32,36,3.
