重庆医学2013，Vol.42Issue(3)：251-254,4.DOI:10.3969/j.issn.1671-8348.2013.03.005
6-巯基嘌呤在HPMCAS包覆介孔分子筛SBA-15药物系统中的缓释行为研究
The study on mesoporous molecular sieve SBA-15 tablet coated with HPMCAS as a drug release carrier for 6-mercaptopurine
摘要
Abstract
Objective To prepare a pH sensitive drug release system hydroxypropyl methylcellulose acetate succinate(HPM CAS)/SBA 15. Methods HPMCAS / SBA 15 was synthesized by coating HPMCAS on a SBA 15. Two kinds of release fluids,in cluding simulated intestinal fluid(SIF,pH = 7.4) and simulated gastric fluid(SGF,pH = 1.2) were used to investigate the drug re lease behavior of the HPMCAS/SBA 15 system. Results In SGF(pH = l. 2), HPMCAS coating materials could effectually delay the release rate of 6 MP. After 4 hours of drug release,the release rate was 12. 5%. However,in SIF(pH = 7. 5; ,no distinct influ ence of the coating materials on the drug delivery rate was found,which was possible that HPMCAS could quickly dissolve into the SIF. After 4 hours of drug release, the release rate rose to 85. 4%. Moreover, it was found that the higher drying temperature of HPMCAS,the better performance of the drug release HPMCAS/SBA 15 system. Conclusion The prepared HPMCAS/SBA 15 system is a good pH sensitive drug carrier.关键词
6-巯基嘌呤/介孔分子筛/pH敏感/药物缓释/醋酸羟丙基甲基纤维素琥珀酸酯Key words
6 mercaptopuriue/ mesoporous molecular sieves/ pH sensitive/ drug release/ hydroxypropyl methylcellulose acetate succinate引用本文复制引用
陈稚,吴都督,何仰芬,陈文芳..6-巯基嘌呤在HPMCAS包覆介孔分子筛SBA-15药物系统中的缓释行为研究[J].重庆医学,2013,42(3):251-254,4.基金项目
2010年广东省教育厅育苗工程 （）
广东省建设中医药强省项目(20111245,20122080) （20111245,20122080）
湛江市科技攻关计划项目(2012C3102014) （2012C3102014）
广东医学院学生创新项目(M2011001). （M2011001）
