重庆医学2013，Vol.42Issue(4)：361-362,366,3.DOI:10.3969/j.issn.1671-8348.2013.04.001
氢气生理盐水对创伤性胰腺炎大鼠氧化应激损伤作用的研究
Effects of hydrogen-rich saline on the oxidative stress injury of traumatic pancreatitis in rats
摘要
Abstract
Objective To investigate the protective effects of hydrogen-rich saline by inhibiting the oxidative stress injury of traumatic pancreatitis in rats. Methods Twenty four male Wistar rats were randomly allocated into 4 groups: sham operation group,traumatic pancreatitis(TP) group,TP treated with normal saline(TP+NS) group and TP treated with hydrogen-rich saline (TP+HS)group. An impact machine was used to produce compressed air to impact the exposed pancreas of rats,and animal models of traumatic pancreatitis were established. The changes in histopathology and the variation of SOD,MDA and GSH were observed 12 h after the operationResults The damage pancreas tissue in TP+HS group are slighter than that in TP+NS group after operation. The levels of plasma MDA are lower in TP+HS group than that in TP+NS group(P＜0. 05). The levels of plasma SOD and GSH are higher in TP+HS group than that in TP + NS group(P＜0.05). Conclusion The current results show that employing hydrogen-rich saline may reduce the damage of traumatic pancreatitis in rat. Its mechanism may be correlated with the inhibition of oxidant stress induced by traumatic pancreatitis.关键词
模型,动物/氢气生理盐水/氧化应激/创伤性胰腺炎Key words
models,animal/hydrogen-rich saline/ oxidative stress/ traumatic pancreatitis引用本文复制引用
骆助林,任建东,田伏洲,汤礼军,汪涛,闫洪涛,黄竹,王华..氢气生理盐水对创伤性胰腺炎大鼠氧化应激损伤作用的研究[J].重庆医学,2013,42(4):361-362,366,3.基金项目
全军医学科学技术研究"十一五"课题资助项目(08Z012). （08Z012）
