重庆医学2013，Vol.42Issue(4)：363-366,4.DOI:10.3969/j.issn.1671-8348.2013.04.002
单核细胞趋化蛋白-1基因-2518G/A多态性与2型糖尿病肾病的相关性研究
A correlation research between the monocyte chemoattractant protein-1 gene -2518G/A polymorphism and diabetic nephropathy
摘要
Abstract
Objective To explore the relationship between monocyte chemoattractant protein-1 gene -2518G/A polymorphism and diabetic nephropathy (DN) in people of Han group in Guangxi. Methods One hundred and thirty patients with type 2 diabetes mellitus were divided into diabetic nephropathy (DN) group and diabetes without diabetic nephropathy (T2DM) group. Eighty healthy people were selected as normal control(NC) group. The genotypes and allele frequencies distribution were assessed by Poly-merase chain reaction-restriction fragment length Polymorphism (PCR-RFLP). Results The values of systolic pressure blood (SBP) ,diastolic blood pressure (DBP) ,urine albumin excretion rate (UAKR) , creatinine (Cr) , and blood urea nitrogen (BUN) in DN group were significantly higher than those of NC or T2DM group (P＜0.05). There was significant difference in the distribution of genotypes and allele frequencies between DN group and NC or T2DM group (P＜0.01). The GG genotypes and G allele frequency distributions in DN group were significantly higher than the NC group and T2DM group (P＜0.01 ,P＜0.05). The G allele carriers had 1. 406 times larger risk for increased incidence of DN compared with healthy controls (P＜0.01, 95%CI:1.112 -1.777). The values of TG,TC and LDL-C were significantly higher among carriers of G allele compared with non-carriers(P＜0. 05). Conclusion The polymorphism of MCP-1-2518G/A is associated with the development of DN in Han nationality in Guangxi province. G allele may be a genetic risk factor incidence of DN.关键词
糖尿病,2型/糖尿病肾病/趋化因子CCL2/多态性,单核苷酸Key words
diabetes mellitus, type 2/diabetic nephropathy/ chemokine CCL2 / polymorphism, single nucleotide引用本文复制引用
王芸,陈军宁,蒋萍萍,李小励,韦家智,李康惠,于健..单核细胞趋化蛋白-1基因-2518G/A多态性与2型糖尿病肾病的相关性研究[J].重庆医学,2013,42(4):363-366,4.基金项目
广西卫生厅课题资助项目(Z2005163). （Z2005163）
