重庆医学2013，Vol.42Issue(4)：379-381,3.DOI:10.3969/j.issn.1671-8348.2013.04.007
18F-FDG-PET/CT融合显像诊断孤立性肺结节的价值
The value of fused 18F-FDG PET/CT images in diagnosing solitary pulmonary nodules
摘要
Abstract
Objective To investigate the differential diagnostic value of integrated 18F-FDG-PET/CT and dual-phase 18F-FDG-PET/CT for solitary pulmonary nodules(SPNs). Methods We performed a retrospective study involving 46 patients referred for SPN characterization with integrated 18F-FDG-PET/CT from January 2009 to January 2010. Of the 46 patients, 21 positive scans underwent dual-phase PET/CT. The differential diagnostic value of 18F-FDG-PET/CT and dual-phase 18F-FDG-PET/CT for SPNs was evaluated according to the definite diagnosis. Results Of the 46 patients with SPNs,twenty-nine cases had malignant SPNs,the other seventeen cases had benign SPNs. The sensitivity,specificity,accuracy,positive predictive value(PPV) ,and negative predictive value(NPV) of integrated 18F-FDG-PET/CT were 96. 55% (28/29), 76.47 (13/17) , 89. 13% (41/46) , 87. 50% (28/32) , and 92. 86 %(13/14) , respectively. Receiver operating characteristic (ROC) analysis showed that SPN with maximum standardized uptake value(SUVmax) greater than 2. 4 was more likely to be malignant with sensitivity of 96. 60% and specificity of 76. 50%. Of the 21 positive results with dual-phase PET/CT,all of the delayed SUV values, whether malignant or benign SPNs,had an increasing tendency in different degrees comparing to the early SUV values, respectively. However, there were no significantly differences between early and delayed SUV values. Conclusion Our study shows that the method of integrated 18 F-FDG-PET/CT takes on highly clinical value in differentiating malignant from benign SPNs,while the diagnosis value of dual-phase technique is limited.关键词
肺肿瘤/18氟-脱氧葡萄糖-正电子发射计算机断层X线体层成像仪/X-CT/孤立性肺结节Key words
lung neoplasms/18F-FDG/PET/CT/X-Ray Computed Tomography/solitary pulmonary nodule引用本文复制引用
邓智勇,刘长江,董燕玉..18F-FDG-PET/CT融合显像诊断孤立性肺结节的价值[J].重庆医学,2013,42(4):379-381,3.基金项目
河北省卫生厅重点科技研究计划资助项目(20090585) （20090585）
承德市科技支撑计划资助项目(200922065). （200922065）
