重庆医学2013，Vol.42Issue(4)：382-384,387,4.DOI:10.3969/j.issn.1671-8348.2013.04.008
大肠癌组织中NRP-2、NRP-1的表达及其与肿瘤淋巴结转移的相关性研究
A research of the expression of NRP-2 and NRP-1 in human colorectal carcinoma and its correlation with the lymph node metastasis of tumor
摘要
Abstract
Objective To detect the expression of NRP-2 and NRP-1 in human colorectal carcinoma and the correlation between the expression of NRP-2,NRP-1 and lymph node metastasis of colorectal carcinoma,and to investigate the role of NRP-2,NRP-1 in the process of the generation and development of colorectal carcinoma. Methods The expression of NRP-2,NRP-1 in the parenchy-matous and the surrounding tissue of malignancies was detected. The correlation between the expression of NRP-2, NRP-1 and lymph node metastasis of colorectal carcinoma was analyzed. Results 1. The positive expression ratio of NRP-2 was 81. 8% in 55 examples of colorectal carcinoma tissue and 14. 5% in the surrounding tissue of malignancies,and the difference had statistical sig-nificance(χ2 =22. 76,P＜0.01). There were much more positive cases of lymph node metastasis in the high expression groups of NRP-2 than the low expression groups of NRP-2(χ2 =10. 69 ,P＜0. 01). 2. The positive expression ratios of NRP-1 were 70. 9% in 55 examples of colorectal carcinoma tissue and 25. 5% in the surrounding tissue of malignancies, and the difference had statistical significance(χ2 =22. 76 ,P＜0.01). And also there were much more positive cases of lymph node metastasis in the high expression groups of NRP-1 than the low expression groups of NRP-1(χ2 = 7. 73,P＜0. 01). 3. The rate of lymph node metastasis in patients that both NRP-2 and NRP-1 were highly expressed was superior to that of low expression of both. Conclusion Both NRP-2 and NRP-1 were overexpressed in colorectal carcinoma,and the positive rate of lymph node metastasis in patients that both NRP-2 and NRP-1 were overexpressed was far superior to the positive rate of low expression of both. Therefor, the expression of NRP-2 and NRP-1 may be statistically positively correlated with the generation and development of colorectal carcinoma,and which may have a synergetic effection.关键词
大肠肿瘤/NRP-2/NRP-1/淋巴结转移Key words
colorectal neoplasms/ NRP-2 / NRP-1/ lymph node metastasis引用本文复制引用
徐卫国,刘和亮,王宇鹏,孙红,王刚,陈源水,董洪超,苗娜,宋旭东,王瑞敏..大肠癌组织中NRP-2、NRP-1的表达及其与肿瘤淋巴结转移的相关性研究[J].重庆医学,2013,42(4):382-384,387,4.基金项目
河北省科技厅资助项目(10276115D). （10276115D）
