重庆医学2013，Vol.42Issue(4)：385-387,3.DOI:10.3969/j.issn.1671-8348.2013.04.009
不同麻醉方式对直肠癌根治术患者免疫功能的影响
The influence of different anesthesia methods for the immune function of the patients with radical resection of rectal carcinoma
季蒙 1陶军 1王庆利 1黎笔熙1
作者信息
- 1. 解放军广州军区武汉总医院麻醉科,武汉,430070
- 折叠
摘要
Abstract
Objective To explore the influence of different anesthesia methods for the immune function of the patients with radical resection of rectal carcinoma. Methods 86 patients on whom the radical resection of rectal carcinoma were performed were divided into 2 groups; group A (n = 40) performed target control infusion of 3 μg/mL propofol and 3 ng/mL remifentanil,and group B(n = 42) performed combined spinal and epidural anesthesia. The variations of vital signs, the levels of IgM,IgG,IgA,the levels of interleukin-6(IL-6) , tumor necrosis factor-α(TNF-α) and T cell subgroup of all the patients in the two groups were analyzed. Results There were no significant differences for the vital sign and IgM,IgA,IgG during the anesthesia and perioperative periods in both groups. The levels of IL-6 and INF-α in group A and group B increased after anesthesia and group A increased more than group B. The T cell subgroups in group A and group B both decreased after anesthesia and group A decreased more than group B. Conclusion Both the target control infusion and combined spinal and epidural anesthesia inhibit the immune function of the patients with radical resection of rectal carcinoma especially cell immune reaction. The combined spinal and epidural anesthesia causes less inhibition of immune function.关键词
麻醉/免疫/直肠肿瘤/靶控输注/腰硬联合Key words
anesthesia/immunity/rectal neoplasms/target control infusion/ combined spinal and epidural引用本文复制引用
季蒙,陶军,王庆利,黎笔熙..不同麻醉方式对直肠癌根治术患者免疫功能的影响[J].重庆医学,2013,42(4):385-387,3.
