重庆医学2013，Vol.42Issue(4)：388-390,3.DOI:10.3969/j.issn.1671-8348.2013.04.010
拉米夫定治疗慢性乙型肝炎患者后外周血T淋巴细胞亚群的变化研究
Analysis of the variations of T-lymphocyte subsets in peripheral blood in chronic hepatitis B patients after the therapy of Lamivudine
摘要
Abstract
Objective To investigate the variations of T-lymphocyte subsets in peripheral blood in chronic hepatitis B patients after the therapy of Lamivudine. Methods Flow cytometry was used to detect the peripheral blood T-lymphocyte subsets in 154 patients of chronic hepatitis B who were divided into two groups according to the expression of HBeAg - the positive group and the negative group. The variations of HBV-DNA, HBeAg,liver function,CD4+ and CD8+T cells in the patients were detected after a 24 weeks therapy of Lamivudine. Results Kither in positive group or negative group, the percentage of CD4 T cells was lower, but higher in CD8+T cells,and both of the two groups had statistical differences compared with controls (P＜0.05). After the antiviral therapy by Lamivudine for 24 weeks, 60. 2% patients HBV-DNA and HBeAg became negative and the expressions of ALT and AST also obviously degraded in HBeAg positive group,meanwhile the expressions of CD4 and CD8 T cells were increasing and had significant differences compared with pre-therapy (P＜0. 05) and in the HBeAg negative group,the expression of HBV-DNA, ALT and AST significantly degraded and the clinical symptoms also improved,furthermore the expression of CD4+T cells obviously increased (P＜0. 05). In addition, the analysis result of T-lymphocyte subsets in peripheral blood showed that the expressions of CD4+T cells and CD8+T cells degraded in the 5 patients whose conditions were not effectively controlled. Conclusion T lymphocyte played extremely important role in the course of disease with hepatitis B virus and Lamivudine could enhance cellular immunity of the patients,and improve the expression of CD4+ T cells and CD8+ T cells.关键词
肝炎,乙型慢性/T淋巴细胞亚群/CD4+T细胞/CD8+T细胞Key words
hepatitis B,chronic/T-lymphocyte subsets/CD4+ T lymphocyte/CD8+ T lymphocyte引用本文复制引用
杭双熊,申红玉,陈敏,王永忠,濮翔科..拉米夫定治疗慢性乙型肝炎患者后外周血T淋巴细胞亚群的变化研究[J].重庆医学,2013,42(4):388-390,3.基金项目
常州市卫生局重大科技项目(ZD201106). （ZD201106）
