摘要
Abstract
Objective To investigate the curative effect of rabeprazole combined with Kuiyu granule on Hp-positive duodenal bulbar ulcer. Methods 120 cases with Hp-positive duodenal bulbar ulcers were randomly and equally divided into treatment group and control group. Rabeprazole combined with Kuiyu granule were used in the treatment group while rabeprazole was used in the control group. The clinical symptom,Hp eradication rate and ulcer healing rate after 4 weeks,and the ulcer relapse rate and Hp reinfection rate after 6 months or 1 year were observed. Results The total effective rate of the treatment group and the control were 100% and 96. 55% respectively, with no significant difference (P＞0. 05). But compared with the control group,the days of complete remission of the treatment group was fewer (P＜0. 05). Four weeks after treatment,the Hp eradication rates in the treatment group and control group were 96. 49% and 91. 38%,the ulcer healing rates were 98. 25% and 93. 1% , respectively, and the difference was not statistically significant (P＞0. 05). Follow-up half 6 months, the Hp re-infection rate were 5. 56% and 17. 31%,the ulcer relapse rate were 3. 7% and 15. 38% , respectively, and the difference was statistically significant (P＜0. 05). Follow-up a year, the Hp re-infection rate were 11. 76 % and 28 % , the ulcer relapse rate were 7.84% and 24 % , respectively, and the difference was statistically significant (P＜0. 05). Conclusion Rabeprazole combined with Kuiyu Granule can quickly relieve the clinical symptom of patients with duodenal bulbar ulcer and decrease the ulcer relapse rates.关键词
螺杆菌,幽门/雷贝拉唑/溃愈颗粒/十二指肠球部溃疡Key words
helicobacter pylori/rabeprazole/Kuiyu granule/duodenal bulbar ulcer
