重庆医学2013，Vol.42Issue(6)：613-615,3.DOI:10.3969/j.issn.1671-8348.2013.06.005
慢性肾脏病患者血清S-腺苷同型半胱氨酸与心血管并发症的关系
Relation ship between serum S-adenosylhomocysteine level and cardiovascular complications in patients with chronic kidney disease
摘要
Abstract
Objective To explore the change of S adenosylhomocysteine (SAH) ,the precursor of homocysteine (Hey) , in pa tients with chronic kidney disease (CKD) and the relationship between serum SAH level and cardiovascular complications (CVD). Methods Fifty five CKD patients and 32 healthy volunteers were included in this study. Serum SAH level was measured by con tinuous cycle enzyme colorimetric method.Serum Hcy level was measured by ELISA.Serum folate and Vitamin B12 levels were measured by automatic immunity analyzer. Results The mean levels of serum Hey and SAH in CKD patients were significantly higher than that in the healthy controls,especially SAH. The mean level of serum SAH in CKD patients with CVD was significantly higher than that of patients without CVD. Logistic regression analysis indicated SAH was an independent risk factor for cardiovas cular disease in patients with CKD. Levels of folate and vitamin B12 do not differ significantly between groups. Conclusion Serum SAH appears to be a much more sensitive indicator of the cardiovascular complications in patients with CKD than Hey. Serum SAH and Hcy level are significantly correlated with serum creatinine level in patients.关键词
心血管疾病/慢性肾脏病/S-腺苷同型半胱氨酸Key words
cardiovascular diseases/chronic kidney disease/S adenosyl homocysteine引用本文复制引用
欧三桃,唐小平,李莹,刘琦,张帆,刘建..慢性肾脏病患者血清S-腺苷同型半胱氨酸与心血管并发症的关系[J].重庆医学,2013,42(6):613-615,3.基金项目
泸州市科技局资助项目(泸市科函[2011]42号). （泸市科函[2011]42号）
