重庆医学2013，Vol.42Issue(7)：736-738,3.DOI:10.3969/j.issn.1671-8348.2013.07.007
同步热放化疗治疗中晚期宫颈癌的近期疗效观察
Observation on short term effects of concurrent hyperthermia and radiochemotherapy in treatment for medium-term and advanced cervical cancer
摘要
Abstract
Objective To explore the efficacy and safety of concurrent hyperthermia and radiochemotherapy in the treatment of stage II b— IIIb cervical cancer. Methods 118 patients with stage II b— IIIb cervical cancer diagnosed by pathology in this hospital from November 2005 to October 2007 were selected and randomly divided into 3 groups. The simple radiotherapy group(RT,38 ca ses) adopted the conventional segmentation whole pelvic field external exposure,once daily,1. 8 Gy,5 times a week;DT 30. 6 Gy postcentral crosspiece lead(4 — 5)cm× (10—11)cm,DT 14. 4 Gy. The total external exposure was 45 — 50. 4 Gy. In DT 27 Gy,the internal exposure was added,once a week,with the point A dose of 42 — 49 Gy. The concurrent radiochemotherapy group(CRT,44 cases) had the same radiotherapy to the RT group and simultaneously received the chemotherapy,DDP 40 mg/m2/week,for 6 cy cles. The concurrent hyperthermia and radiochemotherapy group(H + CRT,36 cases) had the same radiochemotherapy to the CRT group and was simultaneously performed the local hyperthermia in the deep sites of abdominopelvic cavity, maintaining the body centered temperature of 41. 8 —42 ℃ for 60 min,once a week,for 4 times. The short term efficacies were observed among 3 groups. Results The complete extinction rates of local tumor after external exposure 45 Gy in the H +CRT, CRT and RT groups were 66. 7% ,40. 9% and 18. 4% respectively(P<0. 05). Conclusion Concurrent hyperthermia and radiochemotherapy in treating medi um term and advanced cervical cancer may promote the regression of local tumor,increase the remission rate and is completely toler able.关键词
宫颈肿瘤/热疗/放射治疗/化学治疗Key words
cervical tumor/ hyperthermia/ radiotherapy/ chemotherapy引用本文复制引用
高琨,张彩红,陈心秋,李力..同步热放化疗治疗中晚期宫颈癌的近期疗效观察[J].重庆医学,2013,42(7):736-738,3.基金项目
广西卫生厅科研基金资助项目(Z2002188). （Z2002188）
