重庆医学2013，Vol.42Issue(8)：858-860,3.DOI:10.3969/j.issn.1671-8348.2013.08.007
引产方法与胎盘血管生成素Ⅰ和Ⅱ的关系研究
Study of relationship between induction methods with placenta expression of Ang-Ⅰ and Ang-Ⅱ
摘要
Abstract
Objective To investigate the placenta adherence after induced abortion with three methods and its relation with the placenta expression of angiopoietin T (Ang T ) and angiopoietin If (Ang If ). Methods 86 pregnant women requiring to terminate pregnancy of 14 — 24 weeks,were selected and divided into three groups according to the principle of informed consent. The group A (n = 38) was given with oral mifepristone 20mg and misoprostol 0. 4mg by viginal administration,the group B(n = 30) was given with intra amniotic injection of rivanol l00mg and the group C(n = 18) was given with water bag induction. The expression of Ang \ and Ang If was assayed by immunohisto chemical staining. Then the placenta expression of Ang I and Ang II was observed and its relation with placenta adherence after induced labor was compared among 3 kinds of induction method. Results The rate of placenta adherence in the group A was markedly lower than that in the group B and C(P<0. 05). The placenta expression of Ang T was higher in women with placenta adherence than the others(P<0. 05) , but the placenta expression of Ang If was lower in women with placenta adherence than the others(P<0. 05). The placenta expression of Ang T was higher in the group B and C than the group A(P<0. 05) ,but the placenta expression of Ang 2 was lower in the group B and C than the group A(P<0. 05). Conclusion Mid trimester induced abortion with mefepristone and misoprostol has the lower rate of placenta adherence than the others. Mifepristone blocks the progesterone receptor, inhibits the placental vascular network formation and reduces the progester one levels,at the same time,may decrease progesterone dependent Ang T and increase the antagonist Ang If ,which contributes to the degradation of placental blood vessels and results in the placenta stripping more easily.关键词
引产/方法/妊娠中期/米非司酮/血管生成素-Ⅰ/ⅡKey words
labor, induced/methods/pregnancy trimester, second/mifepristone/angiopoietin I / IT引用本文复制引用
曾成英,郭遂群,魏清柱,肖小敏,蒋惠萍..引产方法与胎盘血管生成素Ⅰ和Ⅱ的关系研究[J].重庆医学,2013,42(8):858-860,3.基金项目
广东省人口和计划生育委员会立项资助项目(20100334). （20100334）
