动物营养学报2012，Vol.24Issue(12)：2469-2475,7.DOI:10.3969/j.issn.1006-267x.2012.12.022
槲皮素作为饲料添加剂的急性毒性和致突变性评价
Evaluation of Acute Toxicity and Mutagenicity of Quercetin as a Feed Additive
摘要
Abstract
This trial was conducted to evaluate quercetin safety as a feed additive. Acute toxicity test, Ames test, micronucleus test of bone marrow cells and sperm abnormality test were performed to evaluate quercetin safety. The results showed as follows: median lethal dosage (LD50) of quecertin > 10 g/kg BW; twice results of Ames test with and without liver microsomal polychlorinated biphenyl revulsive ( S9) were negative; the re-sult of micronucleus test of bone marrow cells was negative and there was no cytotoxic effect on experimental animals; the result of mouse sperm abnormality test showed that there was no significant difference in different quecertin treatments (P>0. 05) , and not in a dose-dependent manner, compared with the negative control group. Quercetin is safe as a feed additive.关键词
槲皮素/急性毒性试验/Ames试验/微核试验/精子畸形试验Key words
quercetin/ acute toxicity test/ Ames test/ micronucleus test of mouse bone marrow cells/ mouse sperm abnormality test分类
农业科技引用本文复制引用
冯香安,李壵,刘莹,金芳,张琳,呼林林,索艳丽..槲皮素作为饲料添加剂的急性毒性和致突变性评价[J].动物营养学报,2012,24(12):2469-2475,7.基金项目
哈尔滨市科学技术局科技创新人才研究专项资金(2011RFLXN015) （2011RFLXN015）
