南方医科大学学报2012，Vol.32Issue(12)：1812-1815,4.DOI:10.3969/j.issn.1673-4254.2012.12.028
广州市某体检人群高尿酸血症患病率及相关危险因素分析
Analysis of prevalence and risk factors of hyperuricemia in subjects undergoing routine physical examinations in Guangzhou
摘要
Abstract
Objective To investigate the prevalence and risk factors of hypemricemia in the subjects undergoing routine physical examinations in Guangzhou. Methods This study was conducted among 8302 subjects (5136 male and 3166 female) undergoing routine physical examinations in a hospital in Guangzhou during the period from October 1, 2010 and December 31, 2011. For all the subjects, such indices as body height, weight, waist circumference, hip circumference, blood pressure, heart rate, and blood biochemistry were examined, and the body mass index (BMI) and waist-hip ratio were calculated. The risk factors of hyperuricemia were analyzed using univariate and multivariate logistic regression analysis. Results Hypemricemia was detected in 35.68% of the total subjects, and the detection rates were significantly higher in male than in female subjects (46.83% vs 17.59%, P＜0.0001). Unconditional logistic regression analysis showed a significant correlation of hyperuricemia with age, sex, BMI, hypertension, waist-hip ratio, triglycerides, low-density lipoprotein (LDL), very low-density lipoprotein cholesterol (VLDL-C), creatinine, and blood urea nitrogen (P＜0.05). Multivariate logistic regression analysis identified BMI, blood pressure, waist-hip ratio, hypertriglyceridemia, LDL, VLDL-C, creatinine, and urea nitrogen as the risk factors for hyperuricemia, and age and gender were negatively correlated with the incidence of hyperuricemia with OR values of 0.991 and 0.660, respectively. Conclusion Hyperuricemia has a high prevalence in the subjects undergoing routine physical examinations in Guangzhou. The risk factors of hyperuricemia include hypertension, hypertriglyceridemia, and elevations of BMI, waist-hip ratio, LDL, VLDL-C, creatinine, and blood urea nitrogen. Age and gender can be protective factors against hyperuricemia.关键词
高尿酸血症/体检/患病率/危险因素Key words
hyperuricemia/physical examinations/prevalence/risk factors分类
医药卫生引用本文复制引用
马文峰,陈锦华,王万山,周娅,俞守义..广州市某体检人群高尿酸血症患病率及相关危险因素分析[J].南方医科大学学报,2012,32(12):1812-1815,4.基金项目
广东省科技计划项目(2012B040304010) （2012B040304010）
