南方医科大学学报2013，Vol.33Issue(1)：125-127,3.DOI:10.3969/j.issn.1673-4254.2013.01.27
遗传性和散发性胃癌上皮型钙黏附素的表达和启动子甲基化状态的关系
E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer
摘要
Abstract
Objective To evaluate the role of E-cadherin (E-cad) and CDH1 gene encoding E-cad in the occurrence of sporadic or hereditary gastric cancer. Methods Nineteen normal gastric mucosal issue specimens, 19 specimens of hereditary gastric cancer (diagnosed according to ICG-HGC criteria), and 19 specimens of sporadic gastric cancer examined for E-cad expression and CDH1 promoter methylation using immunohistochemistry and methylation-specific PCR (MSP). Results The protein expression of E-cad were significantly reduced in both of the cancer tissues (P<0.001) compared with that in the normal gastric mucosal tissues, and showed no significant difference between the two cancers (P=0.84). CDH1 promoter hypermethylation was found in 10 out of the 19 hereditary gastric cancer tissues, a rate significantly higher than that in sporadic gastric cancer tissues (3/19, P<0.01). Conclusion CDH1 promoter hypermethylation is probably an important factor contributing to reduced E-cad expression in sporadic gastric cancer but not in hereditary gastric cancer.关键词
胃癌/上皮型钙黏附素/CDH1基因/甲基化Key words
gastric cancer/E-cadherin/CDH1 gene/methylation引用本文复制引用
李晓军,赵阳,任宏..遗传性和散发性胃癌上皮型钙黏附素的表达和启动子甲基化状态的关系[J].南方医科大学学报,2013,33(1):125-127,3.基金项目
陕西省攻关项目(2010R01-130) （2010R01-130）
