南方医科大学学报2013，Vol.33Issue(1)：128-130,3.DOI:10.3969/j.issn.1673-4254.2013.01.28
转录因子SOX2在宫颈上皮内瘤样病变及宫颈癌中的表达及临床意义
Expression of SOX2 in cervical intraepithelial neoplasia and cervical cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of SOX2 in cervical intraepithelial neoplasia (CIN) and cervical cancer and explore its association with the clinical features. Methods SOX2 expressions were examined using immunohistochemical method in 10 normal cervical tissue specimens, 36 cervical intraepithelial neoplasia specimens (including 10 cases of grade 1,12 of grade Ⅱ, and 14 grade III) and 40 cervical cancer specimens (including 21 cases of stage Ⅰ and 19 of stage Ⅱ). The correlation between the immunohistochemical results and the clinical features of the patients was analyzed. Results SOX2 expression was negative in normal cervical tissues, and was positive in 41.6% of CIN specimens (10.0% in CIN Ⅰ, 41.7% in CIN Ⅱ, and 64.3% in CIN Ⅲ) in 82.5% of cervical cancer specimens (78.2% in stage Ⅰ and 88.2% in stage Ⅱ). The patients with cervical cancer had a significantly higher positivity rate of SOX2 than normal control group (P<0.05). The positivity rate of SOX2 increased with the evolution of cervical disease. SOX2 protein expression was significantly correlated with the histological grade and lymph node metastasis (P<0.05), but not with the age or clinical stage of the patients (P>0.05). Conclusion SOX2 expression may serve as a useful indicator for evaluating metastasis and malignancy of cervical cancer.关键词
SOX2/宫颈上皮内瘤样病变/宫颈癌Key words
SOX2/cervical intraepithelial neoplasia/cervical cancer引用本文复制引用
蔡春芳,谭国胜,俞奇,栾峰,余雷,王莹..转录因子SOX2在宫颈上皮内瘤样病变及宫颈癌中的表达及临床意义[J].南方医科大学学报,2013,33(1):128-130,3.基金项目
广东省自然科学基金(S2011040002502) （S2011040002502）
广东省医学科研基金(A2012825) （A2012825）
