儿科药学杂志2013，Vol.19Issue(1)：15-17,3.
肺表面活性物质治疗新生儿重症胎粪吸入综合征疗效观察
The Clinical Effect of Pulmonary Surfactant on Neonatal Severe Meconium Aspiration Syndrome
易明 1段娓 1刘喻1
作者信息
- 1. 重庆市三峡中心医院,重庆万州404000
- 折叠
摘要
Abstract
Objective: To explore the clinical effect of pulmonary surfactant (PS) on severe meconium aspiration syndrome (MAS). Method; fifty two neonates with severe MAS were randomized into a treatment groups (26 cases) and a control group (26 cases). Two groups received standard care, including mechanical ventilation if needed. The treatment group received Pulmonary surfactant 100 - ISO mg/kg additionally. Oxygenabon function, clinical course and outcome of the neonales were observed, collected and statistically analyzed. Result: Oxygenation index of neonates in the treatment group was lower than that in the control group (P<0.05) , and the ratio of alveolar-arterial oxygen gradient of neonates in the treatment group was higher than that in the control group (P<0. 05). Neonates in the treatment group had a shorter duration of mechanical ventilation and hospitalizalion, and lower incidence of pneumothorax and ventilation associated pneumonia ( VAP) than those in the control group (P<0. 05). Conclusions: Pulmonary surfactant can significantly improve the oxygenation function, shorten the duration of mechanical ventilation and hospitalization, and decrease the incidence of pneumothorax and VAP in neonates with MAP.关键词
胎粪吸入综合征/肺表面活性物质/猪肺磷脂注射液/新生儿Key words
Meconium aspiration syndrome/ Pulmonary surfactant/ Poractant alfa injection/ Neonate分类
医药卫生引用本文复制引用
易明,段娓,刘喻..肺表面活性物质治疗新生儿重症胎粪吸入综合征疗效观察[J].儿科药学杂志,2013,19(1):15-17,3.
