摘要
Abstract
Objective: To explore the clinical effect of montelukast soudium in treating children with Henoch-Schonlein Puipura ( HSP). Methods: Ninety six cases of children with HSP were randomly divided into a treatment group and a control group equally. Patients in the two groups were given anlihistamine drugs, calcium, vitamin C, and antibiotic treatment to those with signs of infection. All patients stopped taking food and medications that may cause allergy, and avoided contacting with suspicious allergens. Patients with gastrointestinal bleeding received cimetidine and mucosa protective agent, and had bed rest and fasting. Patients with abdominal pain, joint swelling and pain were given glucocorticoids. Based on the comprehensive therapy, the treatment group was given montelukast soudium chewing tablets, 5 mg/day for <10-year-old children, 10 mg /day for ≥ 10-year-old, once every night before bed, for one month. The effects of the two groups were observed and compared. Results; Total effective rate in the treatment group was 95. 8 % , while in the control group it was 85.4 %. The effect of the treatment group was better. But there was no significant difference between the two groups (x2 = 3. 065, P>0. 05). The durations of cutaneous purpura, gastrointestinal lesions, joint swelling and pain, renal lesions in the treatment group were significantly shorter than those in the control group. There were significant differences between the two groups (P<0.05 ) . Conclusions: Montelukast sodium in treating children with HSP has definite effects and no adverse reactions. It can quickly relieve symptoms, shorten the course of disease, and is worthy of clinical use.关键词
孟鲁司特钠/过敏性紫癜/小儿/疗效Key words
Montelukast sodium/ Henoch-Schonlein purpura/ Children/ Clinical effect分类
医药卫生
