首页|期刊导航|癌症（英文版）|Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma

Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma

Ji-Sheng Li Jian-Ming Ying Xiu-Wen Wang Zhao-Hui Wang Qian Tao Li-Li Li

癌症（英文版）2013，Vol.32Issue(1)：3-11,9.

癌症（英文版）2013，Vol.32Issue(1)：3-11,9.DOI:10.5732/cjc.011.10381

Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma

Ji-Sheng Li ¹Jian-Ming Ying ²Xiu-Wen Wang ¹Zhao-Hui Wang ³Qian Tao ⁴Li-Li Li³

作者信息

1. Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R.China
2. Department of Pathology, Cancer Hospital & Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, P.R.China
3. Cancer Epigenetics Laboratory, Department of Clinical Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong and CUHK Shenzhen Research Institute, Shenzhen, Guangdong 518055, P.R.China
4. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(CAS)-CUHK, Shenzhen, Guangdong 518055, P.R.China
折叠

摘要

Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries.Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression.Recently,many novel TSGs silenced by promoter methylation have been identified in ESCC,and these genes further serve as potential tumor markers for high-risk group stratification,early detection,and prognosis prediction.This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC,providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.

关键词

Tumor suppressor gene/ CpG island/ promoter methylation/ esophageal squamous cell carcinoma/tumor marker

Key words

Tumor suppressor gene/ CpG island/ promoter methylation/ esophageal squamous cell carcinoma/tumor marker

引用本文复制引用

Ji-Sheng Li,Jian-Ming Ying,Xiu-Wen Wang,Zhao-Hui Wang,Qian Tao,Li-Li Li..Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma[J].癌症（英文版）,2013,32(1):3-11,9.

基金项目

This study was supported by NSFC Joint Research Fund for Hong Kong and Macao Young Scholars (No.30928012),National Natural Science Foundation of China (No.81071634,81172582,and 30801344),and Shenzhen Science Fund for Distinguished Young Scholars (No.JC201005270328A). （No.30928012）

癌症（英文版）

OACSCDCSTPCDSCI

ISSN：1000-467X

访问量0

下载量0

段落导航