癌症（英文版）2013，Vol.32Issue(1)：12-20,9.DOI:10.5732/cjc.011.10344
Aberrant promoter CpG methylation and its translational applications in breast cancer
Aberrant promoter CpG methylation and its translational applications in breast cancer
摘要
Abstract
Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations.Recent studies revealed that abnormal gene expression induced by epigenetic changes,including aberrant promoter methylation and histone modification,plays a critical role in human breast carcinogenesis.Silencing of tumor suppressor genes (TSGs) by promoter CpG methylation facilitates cells growth and survival advantages and further results in tumor initiation and progression,thus directly contributing to breast tumorigenesis.Usually,aberrant promoter methylation of TSGs,which can be reversed by pharmacological reagents,occurs at the early stage of tumorigenesis and therefore may serve as a potential tumor marker for early diagnosis and therapeutic targeting of breast cancer.In this review,we summarize the epigenetic changes of multiple TSGs involved in breast pathogenesis and their potential clinical applications as tumor markers for early detection and treatment of breast cancer.关键词
Breast cancer/ tumor suppressor gene/ CpG/ methylation/ tumor markerKey words
Breast cancer/ tumor suppressor gene/ CpG/ methylation/ tumor marker引用本文复制引用
Ting-Xiu Xiang,Ying Yuan,Li-Li Li,Zhao-Hui Wang,Liang-Ying Dan,Yan Chen,Guo-Sheng Ren,Qian Tao..Aberrant promoter CpG methylation and its translational applications in breast cancer[J].癌症（英文版）,2013,32(1):12-20,9.基金项目
This study was supported by grants from the National Natural Science Foundation of China (NSFC)(No.#81072148,#81071634 and #30928012),Natural Science Foundation of Chongqing (No.2010BB5101),and Shenzhen Science Fund for Distinguished Young Scholars (No.JC201005270328A). （NSFC）
