福建农林大学学报（自然科学版）2013，Vol.42Issue(1)：72-76,5.
网箱养殖条件下呋喃西林代谢物SEM在斑点叉尾鮰体内组织分布及消除规律研究
Tissue distribution and elimination rules of the metabolite of Nitrofuranzone SEM residues in channel catfish (Ietalurus punetaus) cultured in cage
摘要
Abstract
Tissue distribution and elimination rules of nitrofuranzone metabolite Semicarbazide (SEM) were investigated in channel catfish. The concentrations of SEM in blood and tissues (muscle, skin, liver, and, kidney) were analyzed by liquid chromatogra-phy tandem mass spectrometric (HPLC-ESI/MS/MS). The results showed that peak concentrations of SEM were (37.5 ±7.45) ng ·mL-1 and (383.3 ±89.20) μg·kg-1 in blood and kidney in 1 hour of drug withdrawal and (33.3 ±8.25) , (168.2 ±43.47) and (105.0 ±48.40) μg·kg-1 in muscle, skin and liver in 2 hours of drug withdrawal respectively. Average concentration of SEM in muscle was 1.1 times to residues determination value in 480 hours, and SEM in blood, skin, liver, and kidney were 1.17, 8.75, 1.0 and 5.47 times respectively in 1080 hours. Average concentrations of SEM were (0.57 ±0.25) ng·mL-1, (0.28 ±0.03) and (0.83 ±0.24) μg·kg-1 in blood, muscle and skin respectively, and were not detected in liver and kidney in 1080 hours (60 d). SEM was not detected in blood and all tissues in 2160 hours (90 d). The elimination half-lives T1/2 were 11.11 d (in blood) , 9.02 d(in skin) , 8.25 d (in muscle) , 7.40 d (in kidney) and 6.71 d (in liver). The concentration of SEM in skin was higher than in muscle and residue time was longer. The average temperature was 28 ℃ during the whole experiment, in those cultured conditions the withdrawal period of SEM was 2520 ℃· d in the channel catfish edible tissues.关键词
斑点叉尾鮰/呋喃西林代谢物/氨基脲/组织分布/消除Key words
channel catfish/ nitrofuranzone metabolite/ semicarbazide (SEM) / tissue distribution/ elimination分类
农业科技引用本文复制引用
刘永涛,艾晓辉,索纹纹,余少梅,陈建武..网箱养殖条件下呋喃西林代谢物SEM在斑点叉尾鮰体内组织分布及消除规律研究[J].福建农林大学学报（自然科学版）,2013,42(1):72-76,5.基金项目
中央及公益性研究院所基本科研业务费专项资金资助项目(2011JBFA19) （2011JBFA19）
公益性行业(农业)科研专项经费资助(201203085) （农业）
中国水产科学研究院基本科研业务费项目(2011C008) （2011C008）
2011年农业部财政项目"水产品质量安全检测"资助. （）
