分析测试学报2013，Vol.32Issue(2)：244-248,5.DOI:10.3969/j.issn.1004-4957.2013.02.018
流动注射化学发光分析法测定片剂甲氧氯普胺
Flow Injection Chemiluminescence Determination of Metoclopramide Tablets
摘要
Abstract
In this paper, based on the obvious enhancing effect of sodium bromide on the NaIO4 -H2 02 — metoclopramide weak chemiluminescence (CL) reaction system under acidic conditions and combined with the flow injection analysis, a new method for the determination of metoclopramide was proposed. Under the optimum conditions, the relative CL intensities were proportional to the metoclo pramide concentrations in the range of 1. 00 × 10-9-1. 20 x 10 -6 g/mL with a detection limit of 3. 5 x 10-10 g/mL. The relative standard deviation(p = 1. 00 x 10-7 g/mL, n = 11) was 2. 5% . The proposed method was successfully applied in the determination of metoclopramide tablets and spiked urine sample with recoveries of 96% -100% . The results were in agreement with that of the standard method关键词
流动注射/化学发光/甲氧氯普胺/NaIO4/H2O2Key words
flow-injection/ chemiluminescence/ metoclopramide/ sodium periodate/ hydrogen per- oxide分类
化学化工引用本文复制引用
熊海涛,唐志华,聂峰,郑行望..流动注射化学发光分析法测定片剂甲氧氯普胺[J].分析测试学报,2013,32(2):244-248,5.基金项目
陕西省自然科学基金(2010JM7016(1)) （2010JM7016(1）
