分析化学2012，Vol.40Issue(10)：1607-1615,9.DOI:10.3724/SP.J.1096.2012.20380
钆基富勒烯磁共振成像分子影像探针的研究进展
Recent Progress of Molecular Imaging Probes Based on Gadofullerenes
摘要
Abstract
Paramagnetic gadofullerenes and their derivatives exhibit much higher relaxivity than commercial Magnevist TM (Gd-DTPA), therefore have become competitive candidates for magnetic (MR) imaging probes. More prominently, the stable fullerene cages are believed to hinder both chemical attack on the inner clusters and the escape of the toxic lanthanide ions, which should effectively suppress the toxicity of naked Gd3+ ions. Some functionalized gadofullerides also available for further conjugation to fabricate multifunctional probes. This review presents the latest finding of magnetic resonance imaging (MRI) probes based on various gadofullerenes, including Gd@C60,Gd@C82 and Gd3N@C80. The derivative strategy dependent relaxivity properties and biodistributions as well as their potential application as nanoplatform for multifunctional probe are reviewed and discussed.关键词
分子影像探针/内嵌金属富勒烯/磁共振成像/综述Key words
Molecular imaging/ Endohedral metallofullerene/ Magnetic resonance imaging/ Review引用本文复制引用
郑俊鹏,甄明明,王春儒,舒春英..钆基富勒烯磁共振成像分子影像探针的研究进展[J].分析化学,2012,40(10):1607-1615,9.基金项目
本文系国家自然科学基金(Nos.21121063,51072200)和NSAF联合基金(No.11076027)资助 （Nos.21121063,51072200）
