分析化学2012，Vol.40Issue(12)：1933-1937,5.DOI:10.3724/SP.J.1096.2012.10542
基于核磁和质谱分析技术的代谢组学在癌症诊断中的应用
Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis
摘要
Abstract
In this review, we aim to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We will briefly introduce the concept of metabolomics and its rela?tionship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have clearly demons?trated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we will discuss the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.关键词
核磁共振波谱/质谱/代谢轮廓分析/代谢组学/癌症诊断/肿瘤学/评述Key words
Nuclear magnetic resonance spectroscopy/ Mass spectrometry/ Metabolic profiling/ Metabolomics/ Cancer diagnosis/ Oncology/ Review引用本文复制引用
顾海巍,亓云鹏,许柠,丁健桦,安艳波,陈焕文..基于核磁和质谱分析技术的代谢组学在癌症诊断中的应用[J].分析化学,2012,40(12):1933-1937,5.基金项目
本文系国家自然科学基金(Nos.21005015,30901981)、国家重大仪器专项(No.2011YQ170067)及普度大学研究基金(美国)项目资助 （Nos.21005015,30901981）
