分析化学2013，Vol.41Issue(2)：263-267,5.DOI:10.3724/SP.J.1096.2013.20443
血清胆红素的近红外光谱无创检测
Noninvasive Measurement of Serum Bilirubin Employing Near-Infrared Spectroscopy
摘要
Abstract
The noninvasive measurement of serum bilirubin has important significance in early diagnosis, estimation, and prognosis diagnosis. A novel method was proposed to measure the serum bilirubin (BIL) noninvasively by the NIR spectroscopy. The experiment was made by collecting at the tip of tongue from 57 volunteers. All the 57 samples were divided into two parts; training set and prediction set by the proportion of 4:1. The prediction models of total BIL, direct BIL and indirect BIL were established by the PLS algorithm and satisfactory results were obtained. Correlation coefficients (R) were 0.9922, 0.9947 and 0.9486; root mean square errors of prediction (RMSEP) were 6. 13 μmol/L, 4. 61 μmol/L and 4. 05 μmol/L. All above have revealed that the method using NIR spectroscopy combined with PLS has been realized the noninvasive measurement of serum bilirubin, and could be a new breakthrough in noninvasive measurement of other human blood components.关键词
血清胆红素/近红外光谱/偏最小二乘/无创Key words
Serum bilirubin/ Near-infrared spectroscopy/ Partial least squares/ noninvasive引用本文复制引用
李刚,李哲,王蒙军,林凌,张宝菊..血清胆红素的近红外光谱无创检测[J].分析化学,2013,41(2):263-267,5.基金项目
本文系国家自然科学基金(No.30973964)、天津市应用基础及前沿技术研究计划(No.11JCZDJC17100)与天津市科技计划项目:科技型中小企业创新基金(No.10ZXCXSY10400)共同资助 （No.30973964）
