高等学校化学学报2013，Vol.34Issue(1)：50-54,5.DOI:10.7503/cjcu20120185
双亲性氧化石墨烯的合成及生物相容性
Synthesis and Biocompatibility of Amphiphilic Graphene Oxide
摘要
Abstract
Amphiphilic functionalization of graphene oxide (GO) is of the essence for its biomedical applications. TWEEN 80-grafted GO was synthesized by a two-step approach. In step 1, GO surface was activated with hexamethylene diisocyanate (HMDI) through a reaction between GO carboxyl or hydroxyl groups and iso-cyanate. HMDI-activated GO was then grafted by TWEEN 80 in step 2, resulting in amphiphilic GO nano-sheets. The fabricated TWEEN 80-grafted GO exhibited excellent dispersibility in various solvents, such as water, chloroform and n-hexane. Furthermore, PC12 and HeLa cells were cultured on TWEEN 80-grafted GO film to assess its cytotoxicity. Cell morphology analysis and cell viability assay( Calcein AM &EthD-l staining and MTT assay) indicated that the as-synthesized amphiphilic GO had good biocompatibility.关键词
双亲性氧化石墨烯/生物相容性/TWEEN 80/六亚甲基二异氰酸酯Key words
Amphiphilic graphene oxide/ Biocompatibility/ TWEEN 80/ Hexamethylene diisocyanate分类
化学化工引用本文复制引用
李宁,张琦,张庆庆,宋琴,齐琳,王龙,唐明亮,靳刚,程国胜..双亲性氧化石墨烯的合成及生物相容性[J].高等学校化学学报,2013,34(1):50-54,5.基金项目
国家自然科学基金青年科学基金(批准号:31101059)资助. （批准号:31101059）
