高等学校化学学报2013，Vol.34Issue(1)：205-209,5.DOI:10.7503/cjcu20120430
聚苯乙烯共价键合磷铵两性离子的结构修饰及血液相容性
Surface Modification of Polystyrene via Covalently-attaching Phosphoryicholine Zwitterion and Its Blood Compatibility
摘要
Abstract
To be more compatible with blood, polystyrene ( PS) was covalently-attached with phosphorylcho-line(l) via ether bond. After activated by chloromethylation reaction, the PS was constructed with compound 1 by the reaction between benzyl chloride and hydroxyl group. The existence of phosphorylcholine structure onto the surface of PS was revealed by attenuated total reflection Fourier transform infrared spectroscopy ( ATR-FTIR) and 1H NMR. The contact angle measurement of grafted PS membrane indicated that the grafted films possessed relatively hydrophilic surface. The blood compatibilities of grafted PS were evaluated by platelet-rich plasma adhesion experiment. The novel segmented PS containing phosphorylcholine structure improved blood compatibility.关键词
聚苯乙烯/磷铵两性离子/表面改性/血小板黏附/抗凝血生物材料Key words
Polystyrene/ Phosphorylcholine zwitterion/ Surface modification/ Platelet adhesion/ Antithrombo-genic biomaterial分类
化学化工引用本文复制引用
金灿,江玉亮,钱涛,韩巧荣,王炳祥,沈健..聚苯乙烯共价键合磷铵两性离子的结构修饰及血液相容性[J].高等学校化学学报,2013,34(1):205-209,5.基金项目
国家自然科学基金(批准号:20874047)和江苏省高校优势学科建设工程资助项目资助. （批准号:20874047）
