高等学校化学学报2013，Vol.34Issue(2)：479-484,6.DOI:10.7503/cjcu20120522
羧基化氧化石墨烯-谷氨酸复合物的抗凝血性能
Anticoagulant Properties on Carboxylated Graphene Oxide-Glutamic Acid Composite
摘要
Abstract
Anticoagulation properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. Carboxylated graphene oxide complexes with L-glutamic acid was prepared. The complexes were characterized by FTIR, static contact angle ( SCA) , XRD and TG. The anticoagulation properties of complexes were evaluated by hemolysis test and recalcification time test. The results show that the L-glutamic acid has been coordinated on graphene oxide sheet layer. The plasma recalcification time were prolonged greatly as compared to whole blood. At lower concentrations, the hemolysis rates was less than 5% , which met the requirements of biomedical materials.关键词
羧基化氧化石墨烯/L-谷氨酸/溶血实验/复钙时间Key words
Carboxylated graphene oxide/ L-Glutamic acid/ Hemolysis test/ Plasma recalcification time分类
化学化工引用本文复制引用
顾皓,周宁琳,樊云婷,王晓丹,李文秀,沈健..羧基化氧化石墨烯-谷氨酸复合物的抗凝血性能[J].高等学校化学学报,2013,34(2):479-484,6.基金项目
江苏省"六大人才高峰"高层次人才项目(批准号:NY-031)、江苏高校优势学科建设工程资助项目(批准号:PAPD)和江苏省产学研前瞻性联合研究项目(批准号:BY2011109)资助. （批准号:NY-031）
