广东医学2013，Vol.34Issue(1)：132-136,5.
甘氨双唑钠联合PLF方案同期放化疗治疗局部晚期鼻咽癌的临床对照研究
Concurrent chemoradiotherapy with sodium glycididazole plus cisplatin and fluorouracil/leucovorin in treatment of local advanced nasopharyngeal carcinoma.
摘要
Abstract
Objective To compare the efficacy between sodium glycididazole combining with cisplatin and flu-orouraci1/leucovorin ( PLF ) in concurrent chemoradiotherapy ( CCRT ) and CCRT alone for local - advanced nasopharyngeal carcinoma ( NPC ). Methods Ninty - one patients with local - advanced ( Ⅲ ~ Ⅳa ) were randomized into chemoradiotherapy with PLF schedule plus sodium glycididazole group ( therapy group, n = 46 ) and chemoradiotherapy with PLF schedule group ( control group, re =45 ). All the patients received radiotherapy and concurrent injection of cisplatin and fluorouracil/leucovorin. In therapy group, additional sodium glycididazole prior to the radiotherapy was given. Results At the radiotherapy dose of 60 Gy, the complete response rates of nasophayngeal tumor and local - regional lymph nodes in therapy group were significantly higher than those in control group ( 93. 5% vs 77. 8% and 89. 1% vs 71. 1% , P <0. 05 ). Three months after therapy, the corresponding complete response rates in therapy group were still significantly higher than those in control group ( 97. 8% vs 84. 4% and 97. 8% vs 82. 2% , P < 0. 05 ). The 1 - , 2 - , and 3 - year disease - free survival rates ( DFS ) in therapy group were 89. 1% , 65. 5% and 54. 5% , respectively; and were 66. 2% , 48. 2% and 38. 6% , respectively, in control group, with significant differences between them ( P =0. 015 ). The 1 - , 2 - , and 3 - year overall survival rates ( OS ) in treatment group were 97. 8% , 87. 9% and 70. 3% , respectively; and were 95. 6% , 75. 0% and 50. 1% , respectively, in control group, with significant differences between the two group ( P = 0. 01 ). No significant difference in acute toxicities or long - term radioactive injury revealed between the two groups. Conclusion Sodium glycididazole plus cisplatin and fluorouracil/leucorovin can accelerate the tumor remission and improve the DFS and OS in patients with local advanced NPC without causing severe toxicity.关键词
鼻咽癌/同期放化疗/放射增敏剂/甘氨双唑钠/临床对照研究Key words
nasopharyngeal cancer/ concurrent chemoradiotherapy/ radiation sensitizer/ sodium glycididazole/ clinical controlled trial引用本文复制引用
李铭仪,刘锦全,张秀萍,陈冬平,李健..甘氨双唑钠联合PLF方案同期放化疗治疗局部晚期鼻咽癌的临床对照研究[J].广东医学,2013,34(1):132-136,5.基金项目
广东省医学科研基金资助项目(编号:A2011289) （编号:A2011289）
