广东医学2013，Vol.34Issue(4)：538-541,4.
HIV/AIDS患者程序死亡分子1的表达与合并机会性感染的关系
The correlation between the expression of programmed death-1 and the complication of opportunistic infection in HIV/AIDS patients.
摘要
Abstract
Objective To investigate the correlation between the expression of Programmed death - 1 ( PD - 1 ) on T lymphocytes and the complication of opportunistic infection in HIV/AIDS patients. Methods The anticoagulant blood samples from 42 health controls and 42 untreated HIV/AIDS patients who had been hospitalized between January 2009 and May 2012 were collected for detection of PD - 1 expression on CD4+ T cells and CD8 + T cells by flow - cytome-try. The correlation of PD - 1 and complication of opportunistic infection was analyzed. Results Significant up - regulation of PD - 1 on CD4 + T cell and CD8 + T cell was revealed in HIV/AIDS complicated with opportunistic infection than those without opportunistic infection or healthy controls ( P < 0. 05 ), and so it was in those without opportunistic infection than healthy controls ( P < 0. 05 ). The expression of PD - 1 was significantly negatively correlated with CD4 + T cell counts ( CD4 + PD - 1: r = - 0. 371, P < 0. 05; CD8 + PD - 1: r = - 0. 479, P < 0. 05 ) and positively correlated with plasma viral loads ( CD4 + PD - 1: r = 0. 340, P < 0. 05; CD8 + PD - 1: r = 0. 360, P < 0. 05 ). The opportunistic infection rate was 100% ( 24/24 ) in HIV/AIDS with CD4 + T cell counts <200 cell/μL, as the PD - 1 positive rates on CD4 + T and CD8 + T cells were 20. 30% and 23. 28% , respectively. The opportunistic infection rate was 12. 50% ( 1/8 ) in HTV/AIDS with CD4 + T cell counts between 300 and 400 cell/μL, as the of PD - 1 positive rates on CD4 + T and on CD8 + T cells were 16. 11% and 16. 83% , respectively. Conclusion The expression of PD - 1 on lymphocytes is closely associated with the complication of opportunistic infection in HIV/AIDS patients, acting as a marker of disease progression.关键词
HIV感染/获得性免疫缺陷综合征/程序死亡分子1/机会性感染Key words
HIV infections/ acquired immunodeficiency syndrome/ programmed death -1/ opportunistic infection引用本文复制引用
谢荣华,欧阳珊珊..HIV/AIDS患者程序死亡分子1的表达与合并机会性感染的关系[J].广东医学,2013,34(4):538-541,4.基金项目
湖南省教育厅科学研究项目(编号:11C0466) （编号:11C0466）
