感染、炎症、修复2012，Vol.13Issue(4)：212-214,封2,4.
阿的平对高功率微波辐射小鼠肺损伤的保护作用
Protective effects of quinacrine on lung injury induced by microwave irradiation in mice
摘要
Abstract
Objective: To investigate the effect of quinacrine on lung injury induced by microwave irradiation in mice. Methods: One hundred and thirty BALB/c mice were randomly divided into four groups: normal control group ( n = 10) , radiation control group (re = 40), quinacrine low-dose group (12.6 mg/kg, re = 40) and quinacrine high-dose group (50.4 mg/kg, re = 40). Mice of the two quinacrine groups received quinacrine by gavage (20 ml/kg) 1 hour before microwave irradiation, and normal saline was given instead of quinacrine in the radiation control group. All animals, except those of normal control group, received 50 mW/cm2 microwave irradiation for 30 minutes. Pathological changes in lung were observed immediately after irradiation, and 1 day, 2 days, 7 days after irradiation in radiation control group and quinacrine groups, and 7 days after irradiation experiment in normal control group. Meanwhile, heat shock protein 70 (HSP70) protein expression in lung was analyzed using Western Blot. Results: Pathological examination showed that 50 mW/cm2 microwave irradiation for 30 minutes induced lung damages as manifested by blood stasis, alveolar epithelial cell shedding, alveolar septal thinning and fracture, and bronchial congestion in mice lungs. However, in quinacrine groups, reduction in lung septal fracture and attenuation of lung tissue congestion were found compared with radiation control group. The improvement were more markedly at 2 days after irradiation, especially in quinacrine high dose group. Microwave irradiation up-regulated the expression of HSP70 to certain degree in lung, while quinacrine pretreatment further up-regulated the expression of HSP70, especially in quinacrine high dose group. Conclusions;The mechanism of quinacrine protection on lung injury induced by microwave irradiation may be attributed to an increase of HSP70 expression.关键词
阿的平/微波/辐射/肺损伤Key words
Quinarrinc/Microwave/Irradiation/Lung injury引用本文复制引用
吴燕,刘淑红,林凯,葛学铭,王飞,苏振涛,周红梅,赵永岐,范明..阿的平对高功率微波辐射小鼠肺损伤的保护作用[J].感染、炎症、修复,2012,13(4):212-214,封2,4.基金项目
国家自然科学基金资助项目(31071042),军队医药科研"十五"专项课题(01L024) （31071042）
