广东药学院学报2012，Vol.28Issue(6)：673-676,4.DOI:10.3969/j.issn.1006-8783.2012.06.022
家族性腺瘤性息肉病基因工程小鼠模型脾脏的病理学研究
Study of the spleen pathological changes in APCmin mice
摘要
Abstract
Objective To investigate the change of spleen histological structure and the function of exiramedullary hematopoietic system in APCmin mice, in which the WNT signaling pathway is sustained activation. Method The spleen was extracted and subjected to histological examination in APCmin mice. And peripheral blood test was also detected in APCmin mice. Result The spleen was significantly enlarged and histological structure was also obviously changed in APCmin mice. Peripheral blood test showed that red blood cell count significantly decreased in APCmin mice. Conclusion Because of the sustained activation of WNT signaling pathway in APCmin mice, the function of spleen hematopoietic system changed and then the peripheral blood components were affected.关键词
WNT信号通路/家族性腺瘤性息肉病模型小鼠/脾脏Key words
WNT signaling pathway/APCmin mice/spleen分类
医药卫生引用本文复制引用
刘翼龙,章倩倩,雷岩,廖梦颖,陈胜霞,丁一,王丽京..家族性腺瘤性息肉病基因工程小鼠模型脾脏的病理学研究[J].广东药学院学报,2012,28(6):673-676,4.基金项目
国家科技部"973"项目(2010CB529702) （2010CB529702）
国家自然科学基金(30900764 （）
21005022) （）
