中国妇幼健康研究2012，Vol.23Issue(6)：703-705,3.DOI:10.3969/j.issn.1673-5293.2012.06.003
MBL与幼儿呼吸道感染疾病的相关性研究
Correlation between MBL and respiratory tract infection of children
陈秋燕 1刘一心2
作者信息
- 1. 深圳市宝安区石岩人民医院,广东,深圳,518108
- 2. 深圳市妇幼保健院,广东,深圳,518048
- 折叠
摘要
Abstract
Objective To explore the correlation between genetic polymorphism of mannose-binding lectin ( MBL ) and three respiratory tract infections of children. Methods The genotypes of MBL gene codon 52, 54 and 57 were detected by polymerase chain reaction and DNA sequencing method. Results The allele frequency of GTC mutation was 0. 16, and no MBL gene codon 52 or 57 mutation case had been found. The allele frequency of GTC of MBL gene codon 54 in recuurent respiratory system infection group was higher than that of control group, and the difference was significant (χ2 =6. 06,P <0. 05 ). There was positive correlation between allele frequency of GTC gene and recurrent respiratory tract infections ( OR =2. 19,95% CI: 1. 03- 4. 65,P <0. 05 ). Conclusion There is polymorphism in MBL gene codon 54. The allele frequency of GTC in recuurent respiratory system infection group increases, and GTC is associated with the susceptibility of children recurrent respiratory tract infections.关键词
甘露聚糖结合凝集素/基因多态性/毛细支气管炎/反复呼吸道感染/急性上呼吸道感染Key words
mannose-binding lectin ( MBL )/ polymorphism/ bronchiolitis/ recurrent respiratory tract infection/ acute upper respiratory system infection分类
医药卫生引用本文复制引用
陈秋燕,刘一心..MBL与幼儿呼吸道感染疾病的相关性研究[J].中国妇幼健康研究,2012,23(6):703-705,3.
