医学分子生物学杂志2012，Vol.9Issue(4)：277-280,4.DOI:10.3870/j.issn.1672-8009.2012.04.000
中国人群XPD-751位点基因多态性与肝细胞癌易感性的Meta分析
A Meta-analysis of the Relationship between XPD-751 Polymorphism and Susceptibility to Hepatocellular Carcinoma in Chinese Population
摘要
Abstract
Objective To examine the relationship between the genetic polymorphism of XPD-751 and the susceptibility to hepatocellular carcinoma ( HCC) in Chinese people. Methods Databases including CBM, CNKI, WANFANG DATA, VIP, Pubmed and Ovid were searched to identify the relevant studies on the relationship between the genetic polymorphism o f XPD-751 and the susceptibility to HCC in Chinese people. The odds ratio ( OR) of XPD genotype distributions in cases-control groups was calculated. The Meta-analysis software RevMan5. 1 was applied to heterogeneity test and pooled OR calculation. Results A total of 6 case-control studies met the criteria and were selected for the Meta-analysis. Among the studies, there were totally 1752 cases of HCC and 1763 cases of control. The pooled OR of the XPD genotype A/A vs. A/C + C/C was 0. 60 (95 % CI = 0.36 - 1.00), which showed statistically significant difference (Z = 6.58, P < 0.00001 ) . Conclusion The genetic polymorphism of XPD may be associated with increased risk for HCC, and the XPD genotype may be a susceptible factor for HCC.关键词
XPD/基因多态性/肝细胞癌/Meta分析Key words
XPD/ genetic polymorphism/ hepatocellular carcinoma/ meta-analysis分类
医药卫生引用本文复制引用
刘君,肖庚富..中国人群XPD-751位点基因多态性与肝细胞癌易感性的Meta分析[J].医学分子生物学杂志,2012,9(4):277-280,4.基金项目
973重要传染病基础研究专项 （）
