国际病理科学与临床杂志2012，Vol.32Issue(6)：524-529,6.DOI:10.3969/j.issn.1672-7347.2012.06.012
MicroRNA靶位点单核苷酸多态性与肿瘤及其药物敏感性的研究进展
Progress in study on single nucleotide polymorphism in microRNA target sites and cancer as well as drug susceptibility
摘要
Abstract
MicroRNAs (miRNAs) are a family of endogenous, small non-coding RNAs that affect posttranscriptional regulation by pairing to the 3'untranslated region (UTR) of messenger RNA (mRNA) of protein-coding genes, therefore affect mRNA stability and repress protein synthesis. Studies have shown that single nucleotide polymorphism in miRNA target sites may affect the role of miRNA in regulation of their target genes, which in turn participates in tumorigenesis, development and drug resistance.关键词
microRNA/单核苷酸多态性/肿瘤/药物敏感性Key words
microRNA/ single nucleotide polymorphism/ tumor/ drug susceptibility引用本文复制引用
王婷,雷小勇..MicroRNA靶位点单核苷酸多态性与肿瘤及其药物敏感性的研究进展[J].国际病理科学与临床杂志,2012,32(6):524-529,6.基金项目
国家自然科学基金(30900625). （30900625）
