国际病理科学与临床杂志2012，Vol.32Issue(6)：536-540,5.DOI:10.3969/j.issn.1672-7347.2012.06.014
FoxO3a与肿瘤的发生和发展
Role of FoxO3a in the occurrence and development of tumors
摘要
Abstract
Forkhead box O (FoxO) 3a is one of the FoxO family members. With the role of tumor suppressor genes, it can regulate the development of a variety of tumors, including breast cancer, prostate cancer, leukemia, glioblastoma, and so oa FoxO3a is regulated by many lands of signaling pathways, particularly the phosphatidylinositol 3-kinase/protein kinase B (PDK/ Akt) signaling pathway. As the target molecule of PI3K/AKT signal pathway, the activity of FoxO3a is regulated by AKT phosphorylation and dephosphorylation. FoxO3a plays an important role in regulation of downstream signaling molecules, such as Bim, FasL, p27kipl transcription, to induce apoptosis of tumor cells. The activity and distribution of FoxO3a can be modulated by drugs. Therefore, FoxO3a is expected to become the new idea of cancer treatment关键词
FoxO3a/肿瘤/基因/信号通路Key words
FoxO3a/ tumor/ gene/ signal pathway引用本文复制引用
何时..FoxO3a与肿瘤的发生和发展[J].国际病理科学与临床杂志,2012,32(6):536-540,5.基金项目
福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724). （JXK200724）
