神经损伤与功能重建2012，Vol.7Issue(6)：407-410,4.DOI:10.3870/sjsscj.2012.06.005
中枢组胺能神经介导异氟烷麻醉后认知功能障碍
Involvement of Central Histaminergic System in Memory Deficits after Isoflurane Anesthesia
摘要
Abstract
Objective; To explore whether histaminergic system participates in memory deficits after isoflurane anesthesia. Methods; The effect of isoflurane on post-anesthesia memory was investigated in male SD rats with one-trial inhibitory avoidance model. The role of histaminergic pathway in isoflurane anesthesia induced memory deficits was explored by microinfusion of GABAA receptor antagnist bicucculline methiodide ( BMI) into tuberomammillary nucleus (TMN). The expression of brain-derived neurotrophic factor (BDNF) in hippocampus was assessed by western blot. Results: The step-through latency and the expression of BDNF decreased after isoflurane anesthesia. The changes were reversed by microinfusing of BMI into TMN 10 min before one-trial inhibitory avoidance training. Conclusion; Central histaminergic system and its mediated BDNF expression in hippocampus may participate in the memory deficits after isoflurane anesthesia.关键词
认知功能障碍/异氟烷/组胺能神经/脑源性神经营养因子Key words
cognition deficits/ isoflurane/ histaminergic neuron/ brain-derived neurotrophic factor分类
医药卫生引用本文复制引用
罗涛,刘志刚,刘敏,赵博,侯家保,夏中元..中枢组胺能神经介导异氟烷麻醉后认知功能障碍[J].神经损伤与功能重建,2012,7(6):407-410,4.基金项目
国家自然科学基金(No.81271205,81102863) （No.81271205,81102863）
湖北省自然科学基金(No.302131889) （No.302131889）
