摘要
Abstract
Objective: To explore the association of acute cerebral infarction with plasma levels of homocysteine (Hcy), cysteine (Cys), Cysteinylglycine (CysGly), total glutathione (GSH), folic acid (FA), and vitamin B12 (B12).Methods: Blood samples were collected from 80 cases of acute cerebral infarction patients and 60 health individuals.Plasma levels of Hcy, Cys, CysGly, and GSH were measured by high-performance liquid chromatography, and plasma levels of FA and VitB12 were measured by radioimmunoassay.The relationships among the plasma levels in the patients were analyzed by Pearson correlation analysis.Results: Plasma levels of Hcy, Cys, and CysGly were significantly increased, but the plasma levels of GSH, FA and VitB12 were significantly decreased (P < 0.01) in the patients relative to the controls.There was a positive correlation between the plasma levels of Hcy and Cys (r=0.6663,P<0.0001).Whereas, negative correlations among the plasma levels Hcy, GSH, FA, and VitB12 were found in the patients (r=-0.6099; r=-0.6032; r=-0.5826, P < 0.05).Conclusion: alterations of Hcy and thiol in association with disturbance plasma GSH, FA, and VitB12 may be involved in the pathogenesis of ischemic stroke.关键词
急性脑梗死/同型半胱氨酸/硫醇物/叶酸/维生素B12Key words
acute cerebral infarction/ homocysteine/ thiol/ folic acid/ vitamin B12分类
医药卫生
