神经损伤与功能重建2013，Vol.8Issue(1)：33-35,3.DOI:10.3870/sjsscj.2013.08.009
拉莫三嗪添加治疗青少年耐药性癫痫的临床研究
Study on Adolescent Drug Resistant Epilepsy by LTG Add-on Therapy
摘要
Abstract
Objective: To assess the lamotrigine (LTG) add-on therapy drug resistant epilepsy (DRE)in adolescents.Methods: Thirty-nine adolescent (drug resistant epilepsy)DRE patients were added withLTG slowly and carefully, and their original antiepileptic drugs were not changed.Results: The retention rate of LTG was 94.9% in 1 year follow-up.The total efficacy was 73.0% , and the seizure-free rate of 16.2%.Side effects were observed in 10.3% out of the patients, including skin rashes.No obvious changes in MMSE scores and academic ranking was recorded.Conclusion: LTG was stably effective in adolescent DRE as an add-on drug, with less side effects and no detectable compromise of cognition on adolescents.关键词
拉莫三嗪/青少年/耐药性癫痫Key words
lamotrigine/ adolescent/ drug resistant epilepsy分类
医药卫生引用本文复制引用
笱玉兰,罗利俊,梅俊华,陈国华..拉莫三嗪添加治疗青少年耐药性癫痫的临床研究[J].神经损伤与功能重建,2013,8(1):33-35,3.基金项目
武汉市卫生局资助项目(NO.WX09C04) （NO.WX09C04）
