广西医学2013，Vol.35Issue(1)：10-12,3.DOI:10.11675/j.issn.0253-4304.2013.01.03
宫颈癌患者血清中血管内皮生长因子C和D及其受体的表达及临床意义
Expression of Vascular Endothelial Growth Factor C and D and Their Receptor in Serum of Patients with Cervical Carcinoma and Their Clinical Significance
摘要
Abstract
Objective To detect vascular endothelial growth factor C and D( VEGF-C and VEGF-D ) and their receptor-3( VEGFR-3 ) levels in serum of patients with cervical cancer, and to explore the correlation of lymph node metastasis with VEGF-C, VEGF-D and VEGFR-3. Methods ELISA was used to detect the expression levels of VEGF-C, VEGF-D and VEGFR-3 in serum of 10 cases of normal cervical tissues,36 cases of cervical intraepithelial neoplasia Ⅲ( CINⅢ group ),33 cases of cervical cancer without lymph node metastasis, 10 cases of cervical cancer with lymph node metastasis. The difference of expression levels of VEGF-C, VEGF-D and VEGFR-3 were compared among different groups. Results ( 1 )The expression level of VEGF-C, VEGF-D and VEGFR-3 in serum of cervical cancer patients without lymph node metastasis was significantly higher than those in normal cervical tissues group and CIN1 group( P <0.05 );( 2 )The expression level of VEGF-C, VEGF-D and VEGFR-3 in serum of cervical cancer patients with lymph node metastasis was significantly higher than that in cervical cancer patients without lymph node metastasis( P <0. 05 );( 3 )There was no significant difference in expression levels of serum VEGF-C, VEGF-D and VEGFR-3 between CINⅢ group and normal cervical tissues group ( P >0. 05 ). Conclusion The expression levels of VEGF-C,VEGF-D and VEGFR-3 are related to lymph node metastasis in patients with cervical cancer,and the expression levels of VEGF-C and VEGF-D are closely related to that of VEGFR-3. Thus, VEGF-C and VEGF-D may increase the incidence of lymph node metastasis in cervical cancer through VEGFR-3 signaling pathway, which may be used as the valuable indicators for predicting lymph node metastasis and prognosis of cervical cancer.关键词
宫颈癌/血管内皮生长因子-C/血管内皮生长因子-D/受体3/淋巴结转移Key words
Cervical cancer/Vascular endothelial growth factor C/Vascular endothelial growth factor D/Receptor-3/Lymph node metastasis分类
医药卫生引用本文复制引用
蒙玉刚,梁春燕,安明..宫颈癌患者血清中血管内皮生长因子C和D及其受体的表达及临床意义[J].广西医学,2013,35(1):10-12,3.基金项目
广西科学研究与技术开发计划项目(1140003A-10) （1140003A-10）
