广西医学2013，Vol.35Issue(1)：13-15,3.DOI:10.11675/j.issn.0253-4304.2013.01.04
人参皂甙Rg3对肺癌荷瘤小鼠免疫功能影响的研究
Study on the Effect of Ginsenoside Rg3 on Immune Function of Tumor-Bearing Mice
摘要
Abstract
Objective To investigate the effect of Ginsenoside Rg3 on the immune function of tumor-bearing mice either lung cancer. Methods Forty-eight tumor-bearing mice with C57BL/6 lung cancer were randomly divided into four groups, high-dose Ginsenoside Rg3 group( Rg3 ,15 mg/kg ), low-dose Ginsenoside Rg3 group( Rg3,5 mg/kg ), cisplatin ( DDP ) group( DDP,0.5 mg/kg) and saline group. The activities of splenic natural killer( NK ) cells, lymphokine activated killer( LAK ) cells, cytotoxic T lymphocyte( CTL ) activity, and serum tumor necrosis f actor( TNF ) level were detected in each group after the administration of tumor-bearing mice was performed. Twelve normal mice as control group. Results The positive rates of Survivin of low-dose Rg3 group,high-dose Rg3 group,DDP group were significantly lower than that of saline group ( P < 0. 05 ); Tumor mass of low-dose Rg3 group, high-dose Rg3 group were less than that of saline group ( P < 0.05), but greater than that of DDP group( P < 0. 01 ); The activities of NK, LAK and CTL, and serum TNF level decreased significantly in saline group compared with the normal controls( P <0.05 );The activities of NK,LAK and CTL, and serum TNF level of DDP group were lower than those of saline group( P <0. 05 ), which increased significantly in low-dose Rg3 group and high-dose Rg3 group compared with those of saline group,DDP group ( P <0.05 ),but lower than those of the normal controls( P <0.05 );There was no significant difference in the activities of NK,LAK and CTL,and serum TNF level between low-dose Rg3 group and high-dose Rg3 group( P >0.05 ). Conclusion Ginsenoside Rg3 can improve specific anti-tumor immune response in tumor-bearing mice significantly.关键词
肺癌/人参皂甙Rg3/免疫功能/小鼠Key words
Lung cancer/Ginsenoside Rg3/Immune function/Mice分类
医药卫生引用本文复制引用
王家晓,张玉梅..人参皂甙Rg3对肺癌荷瘤小鼠免疫功能影响的研究[J].广西医学,2013,35(1):13-15,3.基金项目
广西自然科学基金项目(2010GXNSFA013213) （2010GXNSFA013213）
广西青年基金项目(2011GXNSFB018104) （2011GXNSFB018104）
广西中医药大学重点课题(2D2009003) （2D2009003）
