郑州大学学报（医学版）2012，Vol.47Issue(6)：804-807,4.DOI:10.3969/j.issn.1671-6825.2012.06.017
2-甲氧基雌二醇对4T1、SPC-A1和PC-3细胞的生长抑制作用
Growth inhibition effects of 2-methoxyestradiol on 4T1,SPC-A1 and PC-3 cells
王文佳 1张正全 1贾欣 1李雪冰 1张振中1
作者信息
摘要
Abstract
Aim:To explore growth inhibition effect of 2-methoxyestradiol( 2-ME ) on a variety of tumor cells. Methods: The study object was 4T1 cell strain of rat mastocarcinoma,SPC-A1 cell strain of human pulmonary adenocarcinoma and PC-3 cell strain of human prostate cancer. SRB method was adopted to investigate growth inhibition effect of 2-ME on the above tumor cells. In addition,verapamil and synergic index were used to explore the factors influencing 2-ME anti-cancer effect. Re-SUltS :2-ME had inhibition effects on 4T1 ,SPC-A1 and PC-3 cells with IC50 of 6.11,1. 89 and 5.12 μmol/L,respectively. After verapamil was adopted,the inhibitory rate was significantly higher than that of the single-drug group( P <0.01 ),and IC50 dropped to 2.01,0. 57 and 2.77 μmol/L,respectively,with the synergic index distributed within 0. 77 ~0.43. Conclusion :2-ME has inhibition effects on the three kinds of tumor cells,and verapamil has obvious synergistic effect on 2-ME.关键词
2-甲氧基雌二醇/维拉帕米/协同指数/4T1/SPC-A1细胞/PC-3细胞Key words
2-methoxyestradiol/verapamil/synergic index/4T1 cell/SPC-A1 cell/PC-3 cell分类
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王文佳,张正全,贾欣,李雪冰,张振中..2-甲氧基雌二醇对4T1、SPC-A1和PC-3细胞的生长抑制作用[J].郑州大学学报（医学版）,2012,47(6):804-807,4.
